Top 10 Companies Using Palo Alto Networks for Cybersecurity

Introduction

Palo Alto Networks has established itself as a cornerstone of enterprise cybersecurity, protecting some of the world’s most valuable brands and critical infrastructure. With over 85,000 customers globally, this cybersecurity leader provides next-generation firewalls, cloud security, and AI-powered threat prevention to organizations that cannot afford security breaches.

In this comprehensive guide, we explore the top 10 companies using Palo Alto Networks, examining how these industry leaders leverage advanced security solutions to protect their digital assets, customer data, and business operations.

Top 10 Companies Using Palo Alto Networks

1. Amazon Web Services (AWS)

Amazon’s cloud computing division relies on Palo Alto Networks to secure its massive infrastructure. AWS integrates Palo Alto Networks VM-Series virtual firewalls into its marketplace, enabling customers to deploy enterprise-grade security across their cloud environments. With approximately 1,556,000 employees across the Amazon organization and AWS revenue reaching $120 billion in 2025, the cloud division dominates the market with a 34% share, operating across 33 geographic regions with 105 availability zones worldwide.

The partnership demonstrates how even the world’s largest cloud provider trusts Palo Alto Networks for critical security functions. AWS’s rapid expansion into AI and machine learning services creates new security challenges around protecting training data, securing API endpoints, and preventing unauthorized access to compute clusters, all requiring the advanced security capabilities that Palo Alto Networks delivers.

Industry: Cloud Computing & E-commerce
Employees: 1,556,000 (Amazon total)
Revenue: $120 billion
Key Use Cases: Cloud workload protection, network segmentation, threat prevention
Why They Chose PANW: Scalability, automation capabilities, seamless AWS integration

2. JPMorgan Chase

As America’s largest bank, JPMorgan Chase handles trillions of dollars in transactions annually. The financial giant deploys Palo Alto Networks’ next-generation firewalls and Prisma Cloud platform to protect customer financial data, prevent fraud, and maintain regulatory compliance across global operations. With over 317,000 employees worldwide and annual revenue exceeding $177.6 billion, JPMorgan Chase operates one of the most complex financial infrastructures in the world, serving millions of customers across consumer banking, investment banking, commercial banking, and asset management divisions.

JPMorgan Chase’s implementation of Palo Alto Networks solutions spans its global network, protecting over 5,000 branches and 16,000 ATMs while securing digital banking platforms that serve 57 million active mobile customers. The bank’s security architecture must defend against sophisticated nation-state actors and organized cybercrime groups constantly targeting financial institutions.

Industry: Financial Services
Employees: 317,000+
Revenue: $177.6 billion
Key Use Cases: Data loss prevention, advanced threat protection, compliance management
Why They Chose PANW: Zero Trust architecture, real-time threat intelligence, financial sector expertise

3. Coca-Cola

The beverage giant protects its global supply chain, manufacturing facilities, and customer data using Palo Alto Networks security solutions. With approximately 79,100 employees globally and annual revenue of $47.1 billion, Coca-Cola operates one of the world’s most recognized brands, serving 2.2 billion beverage servings daily across its portfolio of over 500 brands and 3,500 beverages in more than 200 countries.

Coca-Cola’s digital transformation journey requires robust cybersecurity to protect IoT devices, operational technology, and cloud applications. The company’s security infrastructure must protect proprietary formulas, supply chain logistics, point-of-sale systems, and growing e-commerce operations. Palo Alto Networks helps secure both the traditional IT environment and operational technology controlling bottling and distribution operations across hundreds of thousands of retail outlets and coolers worldwide.

Industry: Food & Beverage Manufacturing
Employees: 79,100
Revenue: $47.1 billion
Key Use Cases: IoT security, secure remote access, application visibility
Why They Chose PANW: Comprehensive coverage for OT/IT environments, global threat intelligence

4. Siemens

This German industrial powerhouse secures its smart infrastructure, industrial control systems, and enterprise networks with Palo Alto Networks technology. Employing approximately 312,000 people globally with annual revenue of €75.9 billion ($83.2 billion USD), Siemens operates across Digital Industries, Smart Infrastructure, Mobility, and Siemens Healthineers divisions, managing one of the world’s most complex industrial technology portfolios including power generation, building automation, rail systems, and medical imaging equipment.

Siemens requires military-grade security for critical infrastructure projects spanning energy, transportation, and healthcare sectors worldwide. The company’s solutions control power grids, transportation networks, manufacturing facilities, and hospital systems where security breaches could endanger lives or cause widespread disruption. Palo Alto Networks secures approximately 41,700 patents worth of intellectual property while enabling secure remote access for engineers conducting sensitive research across Industry 4.0 and industrial automation initiatives.

Industry: Industrial Manufacturing & Engineering
Employees: 312,000
Revenue: €75.9 billion / $83.2 billion
Key Use Cases: Industrial cybersecurity, critical infrastructure protection, secure SD-WAN
Why They Chose PANW: OT security expertise, industrial protocol visibility, global support

5. University of California System

The UC system protects research data, student information, and academic networks across 10 campuses using Palo Alto Networks solutions. Employing approximately 280,000 people (California’s second-largest employer) with a total budget exceeding $51 billion (2025-26), the University of California operates one of the world’s largest public research university systems, serving over 280,000 students and conducting groundbreaking research across every scientific discipline at campuses including UC Berkeley, UCLA, and UC San Diego.

UC’s cybersecurity requirements span extraordinary complexity, protecting sensitive research including classified defense projects, medical breakthroughs, and intellectual property from 1,529 inventions disclosed in 2024 alone. The university system also manages electronic health records for 11 million patients served annually by six academic health centers, while safeguarding student data under FERPA regulations across a distributed architecture of ten independent campuses plus multiple medical centers and research facilities.

Industry: Higher Education
Employees: ~280,000
Budget: $51+ billion (2024-25)
Key Use Cases: Research data protection, user identity management, network segmentation
Why They Chose PANW: Scalability for large user bases, granular access controls, threat prevention

6. Shell

The energy giant secures its global operations, from offshore drilling platforms to retail networks, using Palo Alto Networks’ comprehensive security portfolio. Shell’s digital infrastructure spans remote locations with challenging connectivity requirements and high-value intellectual property.

With approximately 96,000 employees worldwide and annual revenue of $289 billion, Shell ranks among the world’s largest energy companies. The company operates across every segment of the oil and gas industry, from exploration and production to refining, chemicals, and retail fuel stations. Shell manages critical infrastructure including offshore platforms, pipelines, refineries, and LNG facilities across more than 70 countries.

The energy sector faces unique cybersecurity threats from nation-state actors targeting critical infrastructure and ransomware groups seeking to disrupt energy supply. Shell’s operational technology environment includes industrial control systems managing high-pressure equipment, chemical processes, and safety systems where security failures could result in environmental disasters or loss of life.

Shell’s digital transformation initiatives include predictive maintenance using IoT sensors, remote operations centers controlling offshore platforms, and customer-facing mobile apps for fuel payment. Palo Alto Networks provides security across this diverse environment, from ruggedized hardware suitable for harsh offshore conditions to cloud security for customer applications. The company’s security architecture must balance operational safety requirements with cybersecurity, ensuring that security controls don’t interfere with critical safety systems.

Industry: Energy & Petroleum
Employees: 96,000
Revenue: $289 billion
Key Use Cases: Remote site security, OT/IT convergence, cloud security, critical infrastructure protection, IoT security
Why They Chose PANW: Ruggedized hardware options, satellite connectivity support, energy sector experience, OT security expertise

7. Adobe

As a leading software company, Adobe protects its creative cloud infrastructure, customer data, and intellectual property with Palo Alto Networks solutions. With approximately 30,700 employees and annual revenue of $21.5 billion, Adobe operates one of the world’s most successful SaaS businesses through its Creative Cloud, Document Cloud, and Experience Cloud platforms that serve millions of creative professionals, enterprises, and marketers globally.

The company faces sophisticated threats targeting intellectual property, including source code for flagship products like Photoshop, Illustrator, and Premiere Pro, while managing vast amounts of customer-created content stored in cloud services. Palo Alto Networks secures Adobe’s development pipelines, cloud infrastructure, and API gateways that process billions of authentication requests daily, with increasing focus on AI/ML security as Adobe expands into AI-powered creative tools and generative AI services.

Industry: Software & Technology
Employees: 30,700
Revenue: $21.5 billion
Key Use Cases: SaaS security, API protection, developer security
Why They Chose PANW: Cloud-native security, DevSecOps integration, scalable architecture

8. Accenture

The global consulting firm secures client engagements, proprietary methodologies, and multi-cloud environments using Palo Alto Networks technology. Accenture’s security requirements span diverse client industries with varying compliance needs and threat landscapes.

Industry: Professional Services & Consulting
Key Use Cases: Multi-tenant security, client data isolation, secure collaboration
Why They Chose PANW: Flexibility for diverse environments, strong partner ecosystem, managed security services

9. BMW Group

The automotive manufacturer protects connected vehicles, smart factories, and customer data using Palo Alto Networks solutions. With approximately 159,100 employees worldwide and annual revenue of €142.4 billion ($154 billion USD), BMW operates as one of the world’s leading premium automobile manufacturers, producing BMW, MINI, and Rolls-Royce branded vehicles across over 30 production sites globally, selling 2.45 million vehicles in 2024.

BMW’s shift toward electric and autonomous vehicles creates new attack surfaces requiring advanced cybersecurity measures. Modern BMW vehicles contain over 100 million lines of code and connect to cloud services for navigation, entertainment, and over-the-air software updates, with over 9 million vehicles now capable of remote upgrades. Palo Alto Networks secures BMW’s entire ecosystem from manufacturing operational technology controlling robotic assembly lines to connected vehicle backend infrastructure, protecting against vehicle hacking attempts, ransomware targeting manufacturing, and intellectual property theft.

Industry: Automotive Manufacturing
Employees: 159,100
Revenue: €142.4 billion / $154 billion
Key Use Cases: Connected car security, manufacturing OT protection, supply chain security
Why They Chose PANW: Automotive industry expertise, IoT security capabilities, German data protection compliance

10. Mayo Clinic

One of America’s premier healthcare institutions trusts Palo Alto Networks to protect patient records, medical devices, and research data. With approximately 83,000 employees and annual revenue of $19.8 billion, Mayo Clinic stands as one of the world’s most respected medical institutions, operating major campuses in Rochester (Minnesota), Phoenix (Arizona), and Jacksonville (Florida), completing 2,834 transplants, performing 155,000 surgeries, and handling 5.4 million outpatient visits including over 1 million digital appointments in 2024.

Healthcare cybersecurity requires HIPAA compliance while maintaining access to life-critical systems and patient information. Mayo manages electronic health records for millions of patients, operates cutting-edge medical equipment connected to networks, and maintains the world’s largest digital pathology archive with over 20 million clinical slides. Palo Alto Networks secures Mayo’s entire healthcare ecosystem including electronic medical record systems, medical device networks, research databases, and telemedicine platforms, enabling HIPAA-compliant data sharing between Mayo’s 13,000 physicians while preventing unauthorized access.

Industry: Healthcare
Employees: 83,000
Revenue: $19.8 billion

Key Use Cases: Medical device security, HIPAA compliance, patient data protection
Why They Chose PANW: Healthcare security expertise, medical IoT visibility, compliance automation

Why Enterprise Leaders Choose Palo Alto Networks

These top companies share common reasons for selecting Palo Alto Networks:

Advanced Threat Prevention: Machine learning and AI-powered threat detection stop zero-day attacks and sophisticated malware before they cause damage.

Zero Trust Architecture: Granular access controls and continuous verification ensure only authorized users access sensitive resources.

Cloud Security Excellence: Prisma Cloud and other cloud-native solutions protect multi-cloud and hybrid environments with consistent policy enforcement.

Comprehensive Visibility: Deep application awareness and user identification provide security teams with actionable intelligence across all network traffic.

Automation Capabilities: Security orchestration and automated response reduce incident response times from hours to minutes.

Global Threat Intelligence: The company’s research team (Unit 42) provides customers with real-time threat intelligence from attacks observed worldwide.

Industry Distribution

Palo Alto Networks serves diverse sectors with specialized solutions:

Financial Services: 18% of enterprise customers
Technology & Software: 16% of enterprise customers
Manufacturing: 14% of enterprise customers
Healthcare: 12% of enterprise customers
Government & Defense: 11% of enterprise customers
Retail & E-commerce: 10% of enterprise customers
Energy & Utilities: 8% of enterprise customers
Education: 6% of enterprise customers
Other Industries: 5% of enterprise customers

Key Products Used by Enterprise Customers

Next-Generation Firewalls (NGFW): Hardware and virtual appliances providing advanced threat prevention at network perimeters and data centers.

Prisma Cloud: Comprehensive cloud-native security platform protecting workloads, containers, and serverless applications across AWS, Azure, and Google Cloud.

Cortex XDR: Extended detection and response platform correlating data from endpoints, networks, and clouds to detect sophisticated attacks.

Prisma Access: Cloud-delivered secure access service edge (SASE) solution enabling secure remote work and branch connectivity.

WildFire: Advanced malware analysis sandbox that analyzes unknown files in real-time to detect zero-day threats.

Implementation Success Factors

Organizations successfully deploying Palo Alto Networks solutions follow these best practices:

Phased Rollout: Starting with critical assets and expanding gradually ensures smooth adoption and staff training.

Integration Planning: Connecting Palo Alto Networks with existing SIEM, SOAR, and identity management systems maximizes security effectiveness.

Policy Optimization: Regular policy reviews and updates maintain security without impacting legitimate business operations.

Staff Training: Investing in security team certification and training ensures organizations fully leverage platform capabilities.

Continuous Monitoring: Establishing 24/7 security operations centers or partnering with managed security providers maintains vigilant threat detection.

Return on Investment

Enterprise customers report significant benefits from Palo Alto Networks deployments:

60% reduction in security incidents within first year
45% decrease in incident response time through automation
70% improvement in threat detection accuracy
50% reduction in total cost of ownership versus legacy solutions
80% faster policy deployment and updates

Frequently Asked Questions

1. What is Palo Alto Networks most known for?

Palo Alto Networks is most recognized for pioneering next-generation firewalls that identify and control applications, users, and content rather than just ports and protocols. The company leads in cloud security, zero trust implementation, and AI-powered threat prevention.

2. How much does Palo Alto Networks cost for enterprise deployments?

Enterprise pricing varies significantly based on deployment size, features, and support levels. Typical costs range from $50,000 to $500,000+ annually for mid-sized enterprises, with larger organizations investing millions for comprehensive global deployments including hardware, subscriptions, and professional services.

3. Is Palo Alto Networks better than Cisco or Fortinet?

Palo Alto Networks consistently ranks highest in Gartner’s Magic Quadrant for network firewalls and leads in cloud security innovation. While Cisco offers broader networking integration and Fortinet provides cost-effective solutions, Palo Alto Networks excels in advanced threat prevention and zero trust architecture for security-focused enterprises.

4. What industries use Palo Alto Networks the most?

Financial services, technology companies, and healthcare organizations represent the largest user base. These industries face stringent regulatory requirements, sophisticated threat actors, and high-value data requiring enterprise-grade security that Palo Alto Networks provides.

5. Does Palo Alto Networks offer managed security services?

Yes, Palo Alto Networks offers managed services through its own team and extensive partner network. Services include 24/7 monitoring, incident response, threat hunting, and security operations center support for organizations lacking internal security expertise.

Conclusion

The world’s most security-conscious organizations trust Palo Alto Networks to protect their most valuable assets. From financial institutions handling trillions in transactions to healthcare providers protecting patient lives, these top companies demonstrate that when security cannot fail, enterprises choose Palo Alto Networks.

As cyber threats grow more sophisticated and digital transformation accelerates, the companies profiled here represent a trend toward comprehensive, AI-powered security platforms that provide visibility, prevention, and automated response across hybrid environments. Their success with Palo Alto Networks solutions provides a roadmap for other organizations seeking enterprise-grade cybersecurity.

Whether you’re evaluating security vendors or researching industry best practices, understanding how these leaders implement Palo Alto Networks offers valuable insights into modern cybersecurity strategy and the platforms trusted by the world’s most targeted organizations.